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Home>Products>Journals and Reviews>>Journals and Reviews>I.Re.Bi.C.>Latest issue
International Review of Biophysical Chemistry (I.Re.Bi.C) - October 2011 (Vol. 2 N. 5) - Papers
International Review of Biophysical Chemistry - Papers
by Ol’ha I.
Bolsunova, Ol’ha O. Brovarets’, Dmytro M. Hovorun, Leonid A. Zaika,
Anatoliy I. Potopalsky Abstract - The conformational diversity of methisazone and prototropic molecular tautomerism of isatin were investigated by means of ab initio calculations at the MP2/6-311++G(2df,pd)//DFT B3LYP/6-311++G(d,p) level of theory. A comprehensive conformational, energetical and polar analysis of the methisazone (1-methyl-1H-indole-2,3-dione 3-thiosemicarbazone), a thiosemicarbazone, was provided. We established that flexibility of the thiosemicarbazone group causes conformational diversity of methisazone molecule. Structural, energetical and electron-topological characteristics of specific intramolecular contacts in methisazone conformers were analyzed. In general, two types of H-bonds (NH…O, CH…N), one type of dihydrogen bond (CH…HN) and three types of van der Waals contacts (N…N, N…O, C…O) were detected by performing electron density topological analysis for all 11 conformers of methisazone. A wide range of biological activity of izatizon based on conformational capacity of methisazone molecule, the main constituent part of this drug, was shortly discussed. Five molecular prototropic tautomers of isatin (1H-indole-2,3-dione) – one diketo and four enol tautomeric forms - were indicated. All five isomers have relative Gibbs free energies within a wide range of ~40 kcal∙mol−1 at physiological temperature. The possible biochemical role of tautomeric forms of isatin was briefly discussed. Copyright © 2011 Praise Worthy Prize S.r.l. - All rights reserved
Keywords: Antiviral, Antitumor and Antifungal Drugs, Isatin, Izatizon, Methisazone, Thiosemicarbazone, Quantum Chemical Investigation.
Abstract - The effect of soy protein intake on liver lipid homeostasis in cholesterol-fed rats was investigated. One hundred and five albino Wistar rats divided into five groups (n = 21) were fed 20% soy protein without cholesterol (A), 20% soy protein + 5% cholesterol (B), 20% soy protein + 10% cholesterol (C), 0% soy protein + 20% cholesterol (D), and 5% soy protein + 20% cholesterol (E) for six weeks. Liver total cholesterol, esterified cholesterol, low density lipoprotein cholesterol and triglyceride levels were significantly reduced (p<0.05) in soy protein fed rats (B and C) when compared with those fed cholesterol with no or minimal soy protein (D and E) supplement respectively. It could thus be concluded that soy protein supplementation reduces hepatic lipid load in hypercholesterolemic rats. Copyright © 2011 Praise Worthy Prize S.r.l. - All rights reserved
Keywords: Soy Protein, Liver Lipids, Cholesterol, Hypercholesterolemia.
Abstract - The study was designed to compare oxidative status of sufferers of a co-morbidity of hypertension and diabetes mellitus who have clinical evidence of sustained well controlle - The study was designed to compare oxidative status of sufferers of a co-morbidity of hypertension and diabetes mellitus who have clinical evidence of sustained well controlled blood sugar and blood pressure with that of apparently healthy controls and to see if the variation of this oxidative status with progression (age) of the co-morbidity differ from the observations in previous studies with sufferers of solitary hypertension or diabetes. Blood samples were collected from co-morbidity sufferers (n = 42; 17 males and 25 females ) and 42 apparently healthy volunteers for the determination of plasma levels of two endogenous antioxidant enzymes (superoxide dismutase, SOD, and catalase, CAT) as well as markers of oxidative damage (malondialdehyde, MDA, and erythrocyte osmotic fragility, EOF). Results obtained showed that the blood levels of both SOD and CAT decreased significantly (P<0.001) as age of co-morbidity increases. Also levels of blood MDA and EOF increased with age of co-morbidity (P<0.001). The variation of these indices with disease age was more statistically significant than that observed in earlier studies with solitary diabetes or hypertension. This study shows that oxidative damage is worse in sufferers of hypertensive and diabetic co-morbidity than in sufferers of solitary diabetes or hypertension. Copyright © 2011 Praise Worthy Prize S.r.l. - All rights reserved
Keywords: Co – morbidity, Oxidative Damage, Antioxidant Status, Disease –Age.
Abstract - Aiming to more stably produce an oligomer form of amyloid beta (i.e., a key intermediate of fibrillogenesis which eventually leads to Alzheimer’s disease), the surface of gold colloids were functionalized with nitro-, phenyl-, chloro-, and methoxy-dibenzyloxy disulfide, and molecular interactions were investigated in a dimethyl sulfoxide environment. The transition of color change was observed at pHo as the pH value was lowered externally. As evidence of disulfide being adsorbed on the colloidal surface, the pHo values were dependent of each substituent of the dibenzyloxy disulfide compounds. The trend of pHo exhibited a parabolic relationship as a function of F-value (Swain-Lupton Field constant). Functionalization of gold colloidal surface with methoxy-dibenzyloxy disulfide achieved larger amplitude in repetitive peak shift between pH 4 and 10 implying a formation of an oligomer under the reversible process. Copyright © 2011 Praise Worthy Prize S.r.l. - All rights reserved
Keywords: Amyloid Beta Peptide, Dibenzyloxy Disulfide, Gold Colloid, Alzheimer’s Disease.
Abstract - In this short review, the use of maps is presented charting the surface distribution of the forces of adhesion, indentation and friction, as obtained with the atomic force microscope for the study of surface homogeneity. Phase-separated polymer blends are chosen as examples to demonstrate the complementarity of the method with the more usual topographical imaging approach. Consequent to recent advances towards the determination of surface energy at the sub-micrometre scale, the mapping of this property is now a realistic possibility. Copyright © 2011 Praise Worthy Prize S.r.l. - All rights reserved
Keywords: Atomic force microscopy, Force-of-adhesion mapping, Indentation mapping, Friction-coefficient mapping, Surface-energy mapping.
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